Organic Electrochemical Transistors Integrated in Flexible Microfluidic Systems and Used for Label-Free DNA Sensing

被引：284

作者：

Lin, Peng ^{[1
,2
]}

Luo, Xiaoteng ^{[3
]}

Hsing, I-Ming ^{[3
]}

Yan, Feng ^{[1
,2
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Mat Res Ctr, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Univ Sci & Technol, Dept Chem & Biomol Engn, Hong Kong, Hong Kong, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 35期

关键词：

NUCLEIC-ACID; IMMOBILIZATION; HYBRIDIZATION; SURFACE; SENSOR; ARRAY;

D O I：

10.1002/adma.201102017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organic electrochemical transistors are integrated in flexible microfluidic systems. A novel label-free DNA sensor is developed based on devices with single-stranded DNA probes immobilized on gate electrodes. These devices successfully detect complementary DNA targets at low concentrations using a pulse-enhanced hybridization technique in microfluidic channels. Organic electrochemical transistors are excellent candidates for flexible, highly sensitive, and low-cost biosensors.

引用

页码：4035 / +

页数：7

共 46 条

[21] Improvement of the Tunable Wettability Property of Poly(3-alkylthiophene) Films [J].

Lin, Peng ;

Yan, Feng ;

Chan, Helen L. W. .

LANGMUIR, 2009, 25 (13) :7465-7470

[22] Microfluidic gating of an organic electrochemical transistor -: art. no. 013503 [J].

Mabeck, JT ;

DeFranco, JA ;

Bernards, DA ;

Malliaras, GG ;

Hocdé, S ;

Chase, CJ .

APPLIED PHYSICS LETTERS, 2005, 87 (01)

[23] Label-free detection and classification of DNA by surface vibration spectroscopy in conjugation with electrophoresis [J].

Miyamoto, K ;

Ishibashi, K ;

Hiroi, K ;

Kimura, Y ;

Ishii, H ;

Niwano, M .

APPLIED PHYSICS LETTERS, 2005, 86 (05) :1-3

[24] Graphene-Based Single-Bacterium Resolution Biodevice and DNA Transistor: Interfacing Graphene Derivatives with Nanoscale and Microscale Biocomponents [J].

Mohanty, Nihar ;

Berry, Vikas .

NANO LETTERS, 2008, 8 (12) :4469-4476

[25] Organic phototransistor based on poly(3-hexylthiophene)/TiO2 nanoparticle composite [J].

Mok, Sheung Man ;

Yan, Feng ;

Chan, Helen L. W. .

APPLIED PHYSICS LETTERS, 2008, 93 (02)

[26] Woven Electrochemical Transistors on Silk Fibers [J].

Muller, Christian ;

Hamedi, Mahiar ;

Karlsson, Roger ;

Jansson, Ronnie ;

Marcilla, Rebeca ;

Hedhammar, My ;

Inganas, Olle .

ADVANCED MATERIALS, 2011, 23 (07) :898-+

[27] DNA detection on transistor arrays following mutation-specific enzymatic amplification [J].

Pouthas, F ;

Gentil, C ;

Côte, D ;

Bockelmann, U .

APPLIED PHYSICS LETTERS, 2004, 84 (09) :1594-1596

[28] Immobilization of oligonucleotide probes on Si3N4 surface and its application to genetic field effect transistor [J].

Sakata, T ;

Kamahori, M ;

Miyahara, Y .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2004, 24 (6-8) :827-832

[29] MOSFET-embedded microcantilevers for measuring deflection in biomolecular sensors [J].

Shekhawat, G ;

Tark, SH ;

Dravid, VP .

SCIENCE, 2006, 311 (5767) :1592-1595

[30] Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control [J].

Sosnowski, RG ;

Tu, E ;

Butler, WF ;

OConnell, JP ;

Heller, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1119-1123

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