Unwebbing the presynaptic web

被引：6

作者：

Zamorano, PL ^{[1
]}

Garner, CC ^{[1
]}

机构：

[1] Univ Alabama, Dept Neurobiol, Birmingham, AL 35294 USA

来源：

NEURON | 2001年 / 32卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(01)00458-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The release of neurotransmitter from nerve terminals occurs at a specialized region of the presynaptic plasma membrane called the active zone. A dense matrix of proteins associated with the active zone, called the presynaptic web, is thought to play a fundamental role in defining these neurotransmitter release sites. In this issue of Neuron, Phillips et al. have identified conditions for the biochemical purification of the presynaptic web and show that the web is comprised of proteins involved in the docking, fusion, and recycling of synaptic vesicles.

引用

页码：3 / 6

页数：4

共 12 条

[1] ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT-BRAIN [J].

COTMAN, CW ;

BANKER, G ;

CHURCHILL, L ;

TAYLOR, D .

JOURNAL OF CELL BIOLOGY, 1974, 63 (02) :441-455

[2] The presynaptic cytomatrix of brain synapses [J].

Dresbach, T ;

Qualmann, B ;

Kessels, MM ;

Garner, CC ;

Gundelfinger, ED .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (01) :94-116

[3] PDZ domains in synapse assembly and signalling [J].

Garner, CC ;

Nash, J ;

Huganir, RL .

TRENDS IN CELL BIOLOGY, 2000, 10 (07) :274-280

[4] Molecular determinants of presynaptic active zones [J].

Garner, CC ;

Kindler, S ;

Gundelfinger, ED .

CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) :321-327

[5] STRUCTURAL COMPONENTS IN THE SYNAPTIC CLEFT CAPTURED BY FREEZE-SUBSTITUTION AND DEEP ETCHING OF DIRECTLY FROZEN CEREBELLAR CORTEX [J].

ICHIMURA, T ;

HASHIMOTO, PH .

JOURNAL OF NEUROCYTOLOGY, 1988, 17 (01) :3-12

[6] Signal-processing machines at the postsynaptic density [J].

Kennedy, MB .

SCIENCE, 2000, 290 (5492) :750-754

[7] THE ORGANIZATION OF CYTOPLASM AT THE PRESYNAPTIC ACTIVE ZONE OF A CENTRAL NERVOUS-SYSTEM SYNAPSE [J].

LANDIS, DMD ;

HALL, AK ;

WEINSTEIN, LA ;

REESE, TS .

NEURON, 1988, 1 (03) :201-209

[8] Protein components of a rat brain synaptic junctional protein preparation [J].

Langnaese, K ;

Seidenbecher, C ;

Wex, H ;

Seidel, B ;

Hartung, K ;

Appeltauer, U ;

Garner, A ;

Voss, B ;

Mueller, B ;

Garner, CC ;

Gundelfinger, ED .

MOLECULAR BRAIN RESEARCH, 1996, 42 (01) :118-122

[9] MORPHOLOGY AND MOLECULAR COMPOSITION OF ISOLATED POST-SYNAPTIC JUNCTIONAL STRUCTURES [J].

MATUS, AI ;

TAFFJONES, DH .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1978, 203 (1151) :135-+

[10]

Peters A., 1991, FINE STRUCTURE NERVO

← 1 2 →