Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness

被引：379

作者：

Xing, Yongzheng ^{[1
,2
]}

Cheng, Enjun ^{[2
]}

Yang, Yang ^{[2
]}

Chen, Ping ^{[3
]}

Zhang, Tao ^{[3
]}

Sun, Yawei ^{[2
]}

Yang, Zhongqiang ^{[1
]}

Liu, Dongsheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[3] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 09期

关键词：

PROTEIN; NANOPARTICLES; APTAMER; RELEASE;

D O I：

10.1002/adma.201003343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easy and versatile approach to construct DNA hydrogels is reported. The DNA building blocks, a Y-scaffold and a linker, can self-assemble into DNA hydrogels by the hybridization of their "sticky ends". It is shown that the DNA hydrogels undergo a sol-gel transition upon heat or enzymatic treatment, and the responsiveness can be adjusted by tailoring the sequence of the building blocks.

引用

页码：1117 / 1121

页数：5

共 43 条

[1] Organization of 'nanocrystal molecules' using DNA [J].

Alivisatos, AP ;

Johnsson, KP ;

Peng, XG ;

Wilson, TE ;

Loweth, CJ ;

Bruchez, MP ;

Schultz, PG .

NATURE, 1996, 382 (6592) :609-611

[2] PHASE-TRANSITIONS IN CROSS-LINKED GELS OF NATURAL POLYMERS [J].

AMIYA, T ;

TANAKA, T .

MACROMOLECULES, 1987, 20 (05) :1162-1164

[3] Self-assembly of a nanoscale DNA box with a controllable lid [J].

Andersen, Ebbe S. ;

Dong, Mingdong ;

Nielsen, Morten M. ;

Jahn, Kasper ;

Subramani, Ramesh ;

Mamdouh, Wael ;

Golas, Monika M. ;

Sander, Bjoern ;

Stark, Holger ;

Oliveira, Cristiano L. P. ;

Pedersen, Jan Skov ;

Birkedal, Victoria ;

Besenbacher, Flemming ;

Gothelf, Kurt V. ;

Kjems, Jorgen .

NATURE, 2009, 459 (7243) :73-U75

[4]

Borzacchiello Assunta, 2009, P9, DOI 10.1007/978-88-470-1104-5_2

[5] Hydrogels for Soft Machines [J].

Calvert, Paul .

ADVANCED MATERIALS, 2009, 21 (07) :743-756

[6] A pH-Triggered, Fast-Responding DNA Hydrogel [J].

Cheng, Enjun ;

Xing, Yongzheng ;

Chen, Ping ;

Yang, Yang ;

Sun, Yawei ;

Zhou, Dejian ;

Xu, Lijin ;

Fan, Qinghua ;

Liu, Dongsheng .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (41) :7660-7663

[7] Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra [J].

He, Yu ;

Ye, Tao ;

Su, Min ;

Zhang, Chuan ;

Ribbe, Alexander E. ;

Jiang, Wen ;

Mao, Chengde .

NATURE, 2008, 452 (7184) :198-U41

[8] Hydrogels for biomedical applications [J].

Hoffman, Allan S. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 :18-23

[9] Asymmetric functionalization of nanoparticles based on thermally addressable DNA interconnects [J].

Huo, Fengwei ;

Lytton-Jean, Abigail K. R. ;

Mirkin, Chad A. .

ADVANCED MATERIALS, 2006, 18 (17) :2304-+

[10] A study of DNA tube formation mechanisms using 4-, 8-, and 12-helix DNA nanostructures [J].

Ke, YG ;

Liu, Y ;

Zhang, JP ;

Yan, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (13) :4414-4421

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