Extrinsic and intrinsic regulation of early natural killer cell development

被引：23

作者：

Boos, Markus D. ^{[2
]}

Ramirez, Kevin ^{[2
]}

Kee, Barbara L. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 40卷 / 03期

关键词：

NK cells; transcription factors; cytokines; stromal cell; lineage commitment;

D O I：

10.1007/s12026-007-8006-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are lymphocytes that play a critical role in both adaptive and innate immune responses. These cells develop from multipotent progenitors in the embryonic thymus and neonatal or adult bone marrow and recent evidence suggests that a subset of these cells may develop in the thymus. Thymus- and bone marrow-derived NK cells have unique phenotypes and functional abilities supporting the hypothesis that the microenvironment dictates the outcome of NK cell development. A detailed understanding of the mechanisms controlling this developmental program will be required to determine how alterations in NK cell development lead to disease and to determine how to harness this developmental program for therapeutic purposes. In this review, we discuss some of the known extrinsic stromal-cell derived factors and cell intrinsic transcription factors that function in guiding NK cell development.

引用

收藏

页码：193 / 207

页数：15

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