Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: efficient synthesis of flavones under mild reaction conditions

被引：69

作者：

Du, Zhiyun ^{[1
]}

Ng, Huifen ^{[2
]}

Zhang, Kun ^{[1
]}

Zeng, Huaqiang ^{[2
]}

Wang, Jian ^{[2
]}

机构：

[1] Guang Dong Univ Technol, Fac Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China

[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 20期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; INHIBITORY-ACTIVITY; O-IODOPHENOLS; ACID; 2'-HYDROXYCHALCONES; FLAVANONES; CHROMONES; CHRYSIN; FACILE; DESIGN;

D O I：

10.1039/c1ob06209c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).

引用

页码：6930 / 6933

页数：4

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