Sensing DNA hybridization via ionic conductance through a nanoporous electrode

被引：104

作者：

Vlassiouk, I ^{[1
]}

Takmakov, P ^{[1
]}

Smirnov, S ^{[1
]}

机构：

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

来源：

LANGMUIR | 2005年 / 21卷 / 11期

关键词：

D O I：

10.1021/la0471644

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show that nanoporous alumina modified with covalently linked DNA can be used to detect target DNA by monitoring the increase in impedance at the electrode upon DNA hybridization, which resulted from blocking the pores to ionic flow. Using cyclic voltammetry, direct current conductance, and impedance spectroscopy we confirm the importance of pore size: the effect is observed with 20-nm-diameter pores and is absent for 200-nm pores.

引用

页码：4776 / 4778

页数：3

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