Layered solids as a ''molecular container'' for pharmaceutical agents: L-tyrosine-intercalated layered double hydroxides

被引：87

作者：

Wei, M

Yuan, Q

Evans, DG

Wang, ZQ

Duan, X ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Minist Educ, Key Lab Sci & Technol Controllable Chem React, Beijing 100029, Peoples R China

[2] Tsing Hua Univ, Dept Chem, Beijing 100084, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2005年 / 15卷 / 11期

关键词：

D O I：

10.1039/b416068a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

L-Tyrosine has been intercalated into NiAl, MgAl and ZnAl layered double hydroxides by coprecipitation. The structure and composition of the intercalated materials have been characterized by X-ray diffraction (XRD) and elemental analysis. It is found that intercalation can inhibit racemization of L- tyrosine under the influence of sunlight, high temperature or ultraviolet light. Therefore, this layered material may have potential application as a "molecular container'' for storing or transporting unstable chiral biomolecules or pharmaceutical agents. In addition, the thermal decomposition of the L- tyrosine intercalated NiAl-LDH has been investigated in detail by means of in situ HT-XRD, in situ FT-IR and TG-DTA. Loss of interlayer water occurs between room temperature and 150 degreesC while decomposition of intercalated L- tyrosine and dehydroxylation of the host layers begin at about 250 degreesC and 300 degreesC respectively.

引用

页码：1197 / 1203

页数：7

共 38 条

[11]

Fogg AM, 1999, ADV MATER, V11, P1466, DOI 10.1002/(SICI)1521-4095(199912)11:17<1466::AID-ADMA1466>3.0.CO

[12]

2-1

[13] Preparation and characterization of hybrid organic-inorganic composite materials using the amphoteric property of amino acids:: Amino acid intercalated layered double hydroxide and montmorillonite [J].

Fudala, A ;

Pálinkó, I ;

Kiricsi, I .

INORGANIC CHEMISTRY, 1999, 38 (21) :4653-4658

[14] TYROSINE FOR DEPRESSION - A DOUBLE-BLIND TRIAL [J].

GELENBERG, AJ ;

WOJCIK, JD ;

FALK, WE ;

BALDESSARINI, RJ ;

ZEISEL, SH ;

SCHOENFELD, D ;

MOK, GS .

JOURNAL OF AFFECTIVE DISORDERS, 1990, 19 (02) :125-132

[15] Regulation of microglial tyrosine phosphorylation in response to neuronal injury [J].

Griffith, R ;

Soria, J ;

Wood, JG .

EXPERIMENTAL NEUROLOGY, 2000, 161 (01) :297-305

[16] EFFECTS OF ORAL L-TYROSINE ADMINISTRATION ON CSF TYROSINE AND HOMOVANILLIC-ACID LEVELS IN PATIENTS WITH PARKINSONS-DISEASE [J].

GROWDON, JH ;

MELAMED, E ;

LOGUE, M ;

HEFTI, F ;

WURTMAN, RJ .

LIFE SCIENCES, 1982, 30 (10) :827-832

[17] THERMAL-CONVERSION OF A LAYERED (MG/AL) DOUBLE HYDROXIDE TO THE OXIDE [J].

HUDSON, MJ ;

CARLINO, S ;

APPERLEY, DC .

JOURNAL OF MATERIALS CHEMISTRY, 1995, 5 (02) :323-329

[18]

Kelly G S, 1999, Altern Med Rev, V4, P249

[19] Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide [J].

Khan, AI ;

Lei, LX ;

Norquist, AJ ;

O'Hare, D .

CHEMICAL COMMUNICATIONS, 2001, (22) :2342-2343

[20]

Lautala P, 2000, DRUG METAB DISPOS, V28, P1385

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