Synthesis of a [2]benzazepine analogue of clavizepine
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作者:
García, A
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机构:Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain
García, A
Paz, S
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机构:Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain
Paz, S
Domínguez, D
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Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, SpainUniv Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain
Domínguez, D
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机构:
[1] Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] Univ Santiago de Compostela, Fac Quim, CSIC, Unidad Asociada, Santiago De Compostela 15706, Spain
The synthesis of N-tosylbenzopyran[2]benzazepinone 2 using a simple protocol for assembly of an azepine ring on the xanthene skeleton is described. Formation of the CC bond between C9 of the xanthen-9-ol 7 and the beta -C of N-tosyl aminoacetaldehyde dimethyl acetal leads to 10, which upon treatment with formaldehyde undergoes ring closure. (C) 2001 Elsevier Science Ltd. All rights reserved.