Synthesis of a [2]benzazepine analogue of clavizepine

被引:9
作者
García, A
Paz, S
Domínguez, D [1 ]
机构
[1] Univ Santiago de Compostela, Fac Quim, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain
[2] Univ Santiago de Compostela, Fac Quim, CSIC, Unidad Asociada, Santiago De Compostela 15706, Spain
关键词
xanthenes; acetals; amino aldehydes; benzazepines; polycyclic heterocyclic compounds;
D O I
10.1016/S0040-4039(00)02100-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of N-tosylbenzopyran[2]benzazepinone 2 using a simple protocol for assembly of an azepine ring on the xanthene skeleton is described. Formation of the CC bond between C9 of the xanthen-9-ol 7 and the beta -C of N-tosyl aminoacetaldehyde dimethyl acetal leads to 10, which upon treatment with formaldehyde undergoes ring closure. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:665 / 667
页数:3
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