New steroidal saponins from the sponge Erylus lendenfeldi

被引：23

作者：

Fouad, M

Al-Trabeen, K

Badran, M

Wray, V

Edrada, R

Proksch, P

Ebel, R ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Pharmazeut Biol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany

[2] Menia Univ, Fac Pharm, Dept Pharmacognosy, El Minia, Egypt

[3] Univ Jordan, Yarmouk Univ, Marine Sci Stn, Aqaba, Jordan

[4] Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany

来源：

ARKIVOC | 2004年

关键词：

marine sponge; steroidal saponin; saponin; antibacterial; antifungal;

D O I：

10.3998/ark.5550190.0005.d03

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Our search for biologically active marine natural products has led to the isolation of two new steroidal saponins, eryloside K ( 2) and eryloside L ( 3) together with the known antitumor and antifungal glycoside eryloside A ( 1) from the organic extract of the sponge Erylus lendenfeldi (Geodiidae) collected in the Red Sea. The structures of the new compounds were elucidated on the basis of comprehensive spectral analyses (H-1, C-13, COSY, HMQC, HMBC and TOCSY NMR) as well as GC/MS analysis to infer the absolute stereochemistry of the sugar moieties. Eryloside K ( 2) is the 24,25-didehydro congener of 1, while eryloside L ( 3) features an unusual 8 alpha, 9 alpha-epoxy-4 alpha-methyl-8,9-secocholesta-7,9( 11), 14-triene skeleton which appears to be unprecedented in nature. Eryloside A ( 1) displayed antibacterial activity against Bacillus subtilis and Escherichia coli together with antifungal activity against Candida albicans.

引用

页码：17 / 27

页数：11

共 24 条

[1] IDENTIFICATION AND CHARACTERIZATION OF 2 NEW METHYLICOSADIENOIC ACIDS FROM ERYLUS-FORMOSUS [J].