The enzymology of clavam and carbapenem biosynthesis

被引：53

作者：

Kershaw, NJ

Caines, MEC

Sleeman, MC

Schofield, CJ

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] Univ Oxford, Chem Res Lab, Oxford Ctr Mol Sci, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 34期

基金：

英国惠康基金;

关键词：

D O I：

10.1039/b505964j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

引用

收藏

页码：4251 / 4263

页数：13

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