The enzymology of clavam and carbapenem biosynthesis

被引：53

作者：

Kershaw, NJ

Caines, MEC

Sleeman, MC

Schofield, CJ

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

[2] Univ Oxford, Chem Res Lab, Oxford Ctr Mol Sci, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 34期

基金：

英国惠康基金;

关键词：

D O I：

10.1039/b505964j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and beta-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

引用

页码：4251 / 4263

页数：13

共 86 条

[41] Expansion of the clavulanic acid gene cluster:: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus [J].

Li, RF ;

Khaleeli, N ;

Townsend, CA .

JOURNAL OF BACTERIOLOGY, 2000, 182 (14) :4087-4095

[42] Biosynthesis and molecular genetics of cephamycins - Cephamycins produced by Actinomycetes [J].

Liras, P .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1999, 75 (1-2) :109-124

[43] Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase [J].

Lloyd, MD ;

Lipscomb, SJ ;

Hewitson, KS ;

Hensgens, CMH ;

Baldwin, JE ;

Schofield, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15420-15426

[44] Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase [J].

Lloyd, MD ;

Merritt, KD ;

Lee, V ;

Sewell, TJ ;

Wha-Son, B ;

Baldwin, JE ;

Schofield, CJ ;

Elson, SW ;

Baggaley, KH ;

Nicholson, NH .

TETRAHEDRON, 1999, 55 (33) :10201-10220

[45] Studies on the active site of deacetoxycephalosporin C synthase [J].

Lloyd, MD ;

Lee, HJ ;

Harlos, K ;

Zhang, ZH ;

Baldwin, JE ;

Schofield, CJ ;

Charnock, JM ;

Garner, CD ;

Hara, T ;

van Scheltinga, ACT ;

Valegård, K ;

Viklund, JAC ;

Hajdu, J ;

Andersson, I ;

Danielsson, Å ;

Bhikhabhai, R .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (05) :943-960

[46]

Maiti SN, 1998, CURR MED CHEM, V5, P441

[47] Molecular genetics of carbapenem antibiotic biosynthesis [J].

McGowan, SJ ;

Holden, MTG ;

Bycroft, BW ;

Salmond, GPC .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1999, 75 (1-2) :135-141

[48] Analysis of bacterial carbapenem antibiotic production genes reveals a novel beta-lactam biosynthesis pathway [J].

McGowan, SJ ;

Sebaihia, M ;

Porter, LE ;

Stewart, GSAB ;

Williams, P ;

Bycroft, BW ;

Salmond, GPC .

MOLECULAR MICROBIOLOGY, 1996, 22 (03) :415-426

[49] β-lactam synthetase:: Implications for β-lactamase evolution [J].

McNaughton, HJ ;

Thirkettle, JE ;

Zhang, ZH ;

Schofield, CJ ;

Jensen, SE ;

Barton, B ;

Greaves, P .

CHEMICAL COMMUNICATIONS, 1998, (21) :2325-2326

[50] Crystal structure of carbapenam synthetase (CarA) [J].

Miller, MT ;

Gerratana, B ;

Stapon, A ;

Townsend, CA ;

Rosenzweig, AC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :40996-41002

← 1 2 3 4 5 6 7 8 9 →