AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stress

被引：46

作者：

Cheng, Ning-Hui ^{[1
]}

机构：

[1] Baylor Univ, USDA ARS, Childrens Nutr Res Ctr, Plant Phys Grp,Baylor Coll Med,Dept Pediat, Houston, TX 77030 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 06期

关键词：

glutaredoxin; oxidative stress; redox signaling; chloroplast; plastid; Arabidopsis thaliana;

D O I：

10.1016/j.febslet.2008.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arabidopsis monothiol glutaredoxin (Grx), AtGRX4, was targeted to chloroplasts/plastids and had high similarity to yeast Grx5. In yeast expression assays, AtGRX4 localized to the mitochondria and suppressed the sensitivity of grx5 cells to oxidants. In addition, AtGRX4 reduced iron accumulation and rescued the lysine auxotrophy of grx5 cells. In planta, AtGRX4 RNA transcripts accumulated in growing tissues. Furthermore, AtGRX4expression was altered under various stresses. Genetic analysis revealed that seedlings of atgrx4 mutants were sensitive to oxidants. Taken together, these results suggest that AtGRX4 may have important functions in plant growth and development under extreme environments. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：848 / 854

页数：7

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