Sex determination in birds:: HINTs from the W sex chromosome?

被引：40

作者：

Smith, Craig A. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

来源：

SEXUAL DEVELOPMENT | 2007年 / 1卷 / 05期

关键词：

ASW; chicken sex determination; HINTW; W sex chromosome; WPKCI;

D O I：

10.1159/000108934

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sex in birds is controlled genetically ( ZZ male: ZW female), but the genetic mechanism remains unclear. While some evidence points to the involvement of Z sex chromosome dosage, other data favour a dominant female- determining gene carried on the W sex chromosome. An intriguing candidate gene located on the chicken W chromosome is HINTW, which encodes an aberrant form of a hydrolase enzyme. In chicken embryos, HINTW is strongly expressed in the gonads and other tissues of ZW ( female) embryos. In vitro biochemical data show that HINTW can interfere with the action of a Z-linked orthologue, HINTZ, which is a bona fide hydrolase enzyme. HINTW is conserved among carinate ( flying) birds, and recent molecular analysis indicates that it has undergone positive selection over evolution. However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination. Copyright (C) 2007 S. Karger AG, Basel.

引用

页码：279 / 285

页数：7

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