Aerosol-assisted synthesis of magnetic mesoporous silica spheres for drug targeting

被引：124

作者：

Ruiz-Hernandez, E.

Lopez-Noriega, A.

Arcos, D.

Izquierdo-Barba, I.

Terasaki, O.

Vallet-Regi, M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

[2] Stockholm Univ, Arrhenius Lab, S-10691 Stockholm, Sweden

来源：

CHEMISTRY OF MATERIALS | 2007年 / 19卷 / 14期

关键词：

D O I：

10.1021/cm0705789

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Spherical silica-based mesoporous materials encapsulating magnetic nanoparticles have been synthesized following an aerosol-assisted route. The influence of nonionic surfactant P123 concentration in the structural and textural parameters has been investigated. Moreover, the effect of adding different amounts of magnetic nanoparticles to the precursor solution has been studied attending to structural, textural, and magnetic properties. The ability of these materials to achieve stability in aqueous solution at physiological pH, and their potential to be magnetically guided, have been evaluated. The microspheres adsorption and release performance have been tested by using ibuprofen as a model drug.

引用

页码：3455 / 3463

页数：9

共 68 条

[31] Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents [J].