Kinetic and thermodynamic control of L-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin D.

被引：66

作者：

Shibata, K

Shingu, K

Vassilev, VP

Nishide, K

Fujita, T

Node, M

Kajimoto, T

Wong, CH

机构：

[1] KYOTO PHARMACEUT UNIV, KYOTO, KYOTO 607, JAPAN

[2] INST PHYS & CHEM RES, FRONTIER RES PROGRAM, WAKO, SAITAMA 35101, JAPAN

[3] SCRIPPS RES INST, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 16期

关键词：

D O I：

10.1016/0040-4039(96)00430-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-Threonine aldolase catalyzes the aldol condensation of gamma-benzyloxybutanal and glycine with high erythrolthreo selectivity under a kinetically controlled condition. The erythro product was used in the synthesis of mycestericin D, a potent immunosupressant. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2791 / 2794

页数：4

共 12 条

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