Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

被引：186

作者：

Manabe, Ichiro ^{[1
,2
]}

机构：

[1] Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Global COE, Grad Sch Med, Tokyo 1138655, Japan

来源：

CIRCULATION JOURNAL | 2011年 / 75卷 / 12期

基金：

日本学术振兴会;

关键词：

Heart failure; Inflammation; Kidney; Metabolic syndrome; PATTERN-RECOGNITION RECEPTORS; ADIPOSE-TISSUE INFLAMMATION; OXIDATION-SPECIFIC EPITOPES; INSULIN-RESISTANCE; T-CELLS; CARDIAC-HYPERTROPHY; MACROPHAGE ACCUMULATION; EXTRACELLULAR-MATRIX; MYOCARDIAL FIBROSIS; IN-VIVO;

D O I：

10.1253/circj.CJ-11-1184

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammation appears to underlie most, if not all, the chronic diseases of today, including cardiovascular disease, type 2 diabetes, chronic kidney disease, Alzheimer's disease and cancer. We have demonstrated that obesity induces chronic local inflammation in adipose tissue. We also found that chronic inflammation is crucially involved in the development of heart failure and chronic kidney disease. In this article, I review recent findings reported by my group and others regarding the mechanisms underlying the chronic inflammatory processes commonly observed in adipose tissue, heart and kidney. I then discuss the key features of the chronic inflammation seen in chronic diseases. (Circ J 2011; 75: 2739-2748)

引用

页码：2739 / 2748

页数：10

共 89 条

[11] Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy
Chevalier, Robert L.
Forbes, Michael S.
Thornhill, Barbara A.
[J]. KIDNEY INTERNATIONAL, 2009, 75 (11) : 1145 - 1152
[12] Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
Chou, Meng-Yun
Fogelstrand, Linda
Hartvigsen, Karsten
Hansen, Lotte F.
Woelkers, Douglas
Shaw, Peter X.
Choi, Jeomil
Perkmann, Thomas
Backhed, Fredrik
Miller, Yury I.
Hoerkkoe, Sohvi
Corr, Maripat
Witztum, Joseph L.
Binder, Christoph J.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) : 1335 - 1349
[13] Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S
Mitchell, G
Barbatelli, G
Murano, I
Ceresi, E
Faloia, E
Wang, SP
Fortier, M
Greenberg, AS
Obin, MS
[J]. JOURNAL OF LIPID RESEARCH, 2005, 46 (11) : 2347 - 2355
[14] Inflammation Bares a Dark Side
Couzin-Frankel, Jennifer
[J]. SCIENCE, 2010, 330 (6011) : 1621 - 1621
[15] Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
Del Re, Dominic P.
Matsuda, Takahisa
Zhai, Peiyong
Gao, Shumin
Clark, Geoffrey J.
Van Der Weyden, Louise
Sadoshima, Junichi
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (10) : 3555 - 3567
[16] Targeting gut microbiota in obesity: effects of prebiotics and probiotics
Delzenne, Nathalie M.
Neyrinck, Audrey M.
Baeckhed, Fredrik
Cani, Patrice D.
[J]. NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (11) : 639 - 646
[17] Islet Inflammation in Type 2 Diabetes From metabolic stress to therapy
Donath, Marc Y.
Schumann, Desiree M.
Faulenbach, Mirjam
Ellingsgaard, Helga
Perren, Aurei
Ehses, Jan A.
[J]. DIABETES CARE, 2008, 31 : S161 - S164
[18] Type 2 diabetes as an inflammatory disease
Donath, Marc Y.
Shoelson, Steven E.
[J]. NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) : 98 - 107
[19] NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, Peter
Kono, Hajime
Rayner, Katey J.
Sirois, Cherilyn M.
Vladimer, Gregory
Bauernfeind, Franz G.
Abela, George S.
Franchi, Luigi
Nunez, Gabriel
Schnurr, Max
Espevik, Terje
Lien, Egil
Fitzgerald, Katherine A.
Rock, Kenneth L.
Moore, Kathryn J.
Wright, Samuel D.
Hornung, Veit
Latz, Eicke
[J]. NATURE, 2010, 464 (7293) : 1357 - U7
[20] Endothelial dysfunction: a comprehensive appraisal
Esper, Ricardo J.
Nordaby, Roberto A.
Vilarino, Jorge O.
Paragano, Antonio
Cacharron, Jose L.
Machado, Rogelio A.
[J]. CARDIOVASCULAR DIABETOLOGY, 2006, 5 (1)

← 1 2 3 4 5 6 7 8 9 →