Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

被引:186
作者
Manabe, Ichiro [1 ,2 ]
机构
[1] Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Global COE, Grad Sch Med, Tokyo 1138655, Japan
基金
日本学术振兴会;
关键词
Heart failure; Inflammation; Kidney; Metabolic syndrome; PATTERN-RECOGNITION RECEPTORS; ADIPOSE-TISSUE INFLAMMATION; OXIDATION-SPECIFIC EPITOPES; INSULIN-RESISTANCE; T-CELLS; CARDIAC-HYPERTROPHY; MACROPHAGE ACCUMULATION; EXTRACELLULAR-MATRIX; MYOCARDIAL FIBROSIS; IN-VIVO;
D O I
10.1253/circj.CJ-11-1184
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammation appears to underlie most, if not all, the chronic diseases of today, including cardiovascular disease, type 2 diabetes, chronic kidney disease, Alzheimer's disease and cancer. We have demonstrated that obesity induces chronic local inflammation in adipose tissue. We also found that chronic inflammation is crucially involved in the development of heart failure and chronic kidney disease. In this article, I review recent findings reported by my group and others regarding the mechanisms underlying the chronic inflammatory processes commonly observed in adipose tissue, heart and kidney. I then discuss the key features of the chronic inflammation seen in chronic diseases. (Circ J 2011; 75: 2739-2748)
引用
收藏
页码:2739 / 2748
页数:10
相关论文
共 89 条
  • [31] Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy
    Haudek, Sandra B.
    Cheng, Jizhong
    Du, Jie
    Wang, Yanlin
    Hermosillo-Rodriguez, Jesus
    Trial, JoAnn
    Taffet, George E.
    Entman, Mark L.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2010, 49 (03) : 499 - 507
  • [32] Proinflammatory cytokines in heart failure: double-edged swords
    Hedayat, Mona
    Mahmoudi, Mohammad Jafar
    Rose, Noel R.
    Rezaei, Nima
    [J]. HEART FAILURE REVIEWS, 2010, 15 (06) : 543 - 562
  • [33] HINGLAIS N, 1994, LAB INVEST, V70, P286
  • [34] Inflammation and metabolic disorders
    Hotamisligil, Goekhan S.
    [J]. NATURE, 2006, 444 (7121) : 860 - 867
  • [35] Bone Marrow-Derived Cells Contribute to Vascular Inflammation but Do Not Differentiate Into Smooth Muscle Cell Lineages
    Iwata, Hiroshi
    Manabe, Ichiro
    Fujiu, Katsuhito
    Yamamoto, Tetsufumi
    Takeda, Norifumi
    Eguchi, Kosei
    Furuya, Akiko
    Kuro-o, Makoto
    Sata, Masataka
    Nagai, Ryozo
    [J]. CIRCULATION, 2010, 122 (20) : 2048 - U147
  • [36] Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload
    Izumiya, Y
    Shiojima, I
    Sato, K
    Sawyer, DB
    Colucci, WS
    Walsh, K
    [J]. HYPERTENSION, 2006, 47 (05) : 887 - 893
  • [37] High- but not low-molecular weight FGF-2 causes cardiac hypertrophy in vivo;: possible involvement of cardiotrophin-1
    Jiang, Zhi-Sheng
    Jeyaraman, Madhumathy
    Wen, Ge-Bo
    Fandrich, Robert R.
    Dixon, Ian M. C.
    Cattini, Peter A.
    Kardami, Elissavet
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 (01) : 222 - 233
  • [38] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    Kadowaki, Takashi
    Yamauchi, Toshimasa
    Kubota, Naoto
    Hara, Kazuo
    Ueki, Kohjiro
    Tobe, Kazuyuki
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) : 1784 - 1792
  • [39] T-lymphocyte infiltration in visceral adipose tissue -: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    Kintscher, Ulrich
    Hartge, Martin
    Hess, Katharina
    Foryst-Ludwig, Anna
    Clemenz, Markus
    Wabitsch, Martin
    Fischer-Posovszky, Pamela
    Barth, Thomas F. E.
    Dragun, Duska
    Skurk, Thomas
    Hauner, Hans
    Blueher, Matthias
    Unger, Thomas
    Wolf, Anna-Maria
    Knippschild, Uwe
    Hombach, Vinzenz
    Marx, Nikolaus
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (07) : 1304 - 1310
  • [40] TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure
    Kleinbongard, Petra
    Heusch, Gerd
    Schulz, Rainer
    [J]. PHARMACOLOGY & THERAPEUTICS, 2010, 127 (03) : 295 - 314