Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

被引：186

作者：

Manabe, Ichiro ^{[1
,2
]}

机构：

[1] Univ Tokyo, Dept Cardiovasc Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Global COE, Grad Sch Med, Tokyo 1138655, Japan

来源：

CIRCULATION JOURNAL | 2011年 / 75卷 / 12期

基金：

日本学术振兴会;

关键词：

Heart failure; Inflammation; Kidney; Metabolic syndrome; PATTERN-RECOGNITION RECEPTORS; ADIPOSE-TISSUE INFLAMMATION; OXIDATION-SPECIFIC EPITOPES; INSULIN-RESISTANCE; T-CELLS; CARDIAC-HYPERTROPHY; MACROPHAGE ACCUMULATION; EXTRACELLULAR-MATRIX; MYOCARDIAL FIBROSIS; IN-VIVO;

D O I：

10.1253/circj.CJ-11-1184

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammation appears to underlie most, if not all, the chronic diseases of today, including cardiovascular disease, type 2 diabetes, chronic kidney disease, Alzheimer's disease and cancer. We have demonstrated that obesity induces chronic local inflammation in adipose tissue. We also found that chronic inflammation is crucially involved in the development of heart failure and chronic kidney disease. In this article, I review recent findings reported by my group and others regarding the mechanisms underlying the chronic inflammatory processes commonly observed in adipose tissue, heart and kidney. I then discuss the key features of the chronic inflammation seen in chronic diseases. (Circ J 2011; 75: 2739-2748)

引用

页码：2739 / 2748

页数：10

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