Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

被引：605

作者：

Galli, Stephen J. ^{[1
]}

Grimbaldeston, Michele ^{[1
,2
]}

Tsai, Mindy ^{[1
]}

机构：

[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[2] Inst Med & Vet Sci, Div Human Immunol, Hanson Inst, Adelaide, SA 5000, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1038/nri2327

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.

引用

页码：478 / U14

页数：9

共 95 条

[11] DECREASED NEUTROPHILS AND MEGAKARYOCYTES IN ANEMIC MICE OF GENOTYPE W/W [J].

CHERVENI.PA ;

BOGGS, DR .

JOURNAL OF CELLULAR PHYSIOLOGY, 1969, 73 (01) :25-&

[12] New and emerging roles for mast cells in host defence [J].

Dawicki, Wojciech ;

Marshall, Jean S. .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (01) :31-38

[13] Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia [J].

Demeure, CE ;

Brahimi, K ;

Hacini, F ;

Marchand, F ;

Péronet, R ;

Huerre, M ;

St-Mezard, P ;

Nicolas, JF ;

Brey, P ;

Delespesse, G ;

Mécheri, S .

JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :3932-3940

[14] Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites [J].

Depinay, Nadya ;

Hacini, Feriel ;

Beghdadi, Walid ;

Peronet, Roger ;

Mecheri, Salaheddine .

JOURNAL OF IMMUNOLOGY, 2006, 176 (07) :4141-4146

[15] Critical protective role of mast cells in a model of acute septic peritonitis [J].

Echtenacher, B ;

Mannel, DN ;

Hultner, L .

NATURE, 1996, 381 (6577) :75-77

[16] Current concepts: The asthma epidemic [J].

Eder, Waltraud ;

Ege, Markus J. ;

von Mutius, Erika .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (21) :2226-2235

[17] Loss of histochernical identity in mast cells lacking carboxypeptidase A [J].

Feyerabend, TB ;

Hausser, H ;

Tietz, A ;

Blum, C ;

Hellman, L ;

Straus, AH ;

Takahashi, HK ;

Morgan, ES ;

Dvorak, AM ;

Fehling, HJ ;

Rodewald, HR .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (14) :6199-6210

[18]

FRANDJI P, 1993, J IMMUNOL, V151, P6318

[19] Mast cells as "tunable" effector and immunoregulatory cells: Recent advances [J].

Galli, SJ ;

Kalesnikoff, J ;

Grimbaldeston, MA ;

Piliponsky, AM ;

Williams, CMM ;

Tsai, M .

ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :749-786

[20] Mast cells in the development of adaptive immune responses [J].

Galli, SJ ;

Nakae, S ;

Tsai, M .

NATURE IMMUNOLOGY, 2005, 6 (02) :135-142

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