The bacterial toxin toolkit

被引：112

作者：

Schiavo, G

van der Goot, FG

机构：

[1] Imperial Canc Res Fund, London WC2A 3PX, England

[2] Dept Biochim, CH-1211 Geneva 4, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/35080089

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurls, interfering with fundamental host functions. However, toxins are not only useful to the bacteria - they have also become an essential asset for life scientists, who can now use them as toolkits to explore cellular processes.

引用

收藏

页码：530 / 537

页数：8

相关论文

共 73 条

[1] Adventures of a pore-forming toxin at the target cell surface [J].

Abrami, L ;

Fivaz, M ;

van der Goot, FG .

TRENDS IN MICROBIOLOGY, 2000, 8 (04) :168-172

[2] A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum [J].

Abrami, L ;

Fivaz, M ;

Glauser, PE ;

Parton, RG ;

van der Goot, FG .

JOURNAL OF CELL BIOLOGY, 1998, 140 (03) :525-540

[3]

Alouf J. E, 1999, COMPREHENSIVE SOURCE, V2nd

[4] Postsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila [J].

Baines, RA ;

Robinson, SG ;

Fujioka, M ;

Jaynes, JB ;

Bate, M .

CURRENT BIOLOGY, 1999, 9 (21) :1267-1270

[5] The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin [J].

Barth, H ;

Hofmann, F ;

Olenik, C ;

Just, I ;

Aktories, K .

INFECTION AND IMMUNITY, 1998, 66 (04) :1364-1369

[6] Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: Prototypes of pore-forming bacterial cytolysins [J].

Bhakdi, S ;

Bayley, H ;

Valeva, A ;

Walev, I ;

Walker, B ;

Weller, U ;

Kehoe, M ;

Palmer, M .

ARCHIVES OF MICROBIOLOGY, 1996, 165 (02) :73-79

[7] Toxins from anaerobic bacteria: specificity and molecular mechanisms of action [J].

Boquet, P ;

Munro, P ;

Fiorentini, C ;

Just, I .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (01) :66-74

[8] Microbial toxins and the glycosylation of Rho family GTPases [J].

Busch, C ;

Aktories, K .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (05) :528-535

[9] Snare-mediated membrane fusion [J].

Chen, YA ;

Scheller, RH .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (02) :98-106

[10] Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi [J].

Cortes-Bratti, X ;

Chaves-Olarte, E ;

Lagergård, T ;

Thelestam, M .

INFECTION AND IMMUNITY, 2000, 68 (12) :6903-6911

← 1 2 3 4 5 6 7 8 →