The function and synthesis of ribosomes

被引：162

作者：

Lafontaine, DLJ

Tollervey, D

机构：

[1] Free Univ Brussels, Dept Biol Mol, FNRS, IRMW, B-1070 Brussels, Belgium

[2] Univ Edinburgh, Wellcome Trust, Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/35080045

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Structural analyses of the large and small ribosomal subunits have allowed us to think about how they work in more detail than ever before. The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of antibiotics.

引用

收藏

页码：514 / 520

页数：7

相关论文

共 64 条

[1] Structure of the S15,S18-rRNA complex: Assembly of the 30S ribosome central domain [J].

Agalarov, SC ;

Prasad, GS ;

Funke, PM ;

Stout, CD ;

Williamson, JR .

SCIENCE, 2000, 288 (5463) :107-112

[2] Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle [J].

Agrawal, RK ;

Spahn, CMT ;

Penczek, P ;

Grassucci, RA ;

Nierhaus, KH ;

Frank, J .

JOURNAL OF CELL BIOLOGY, 2000, 150 (03) :447-459

[3] Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome [J].

Agrawal, RK ;

Penczek, P ;

Grassucci, RA ;

Li, YH ;

Leith, A ;

Nierhaus, KH ;

Frank, J .

SCIENCE, 1996, 271 (5251) :1000-1002

[4] Visualization of elongation factor G on the Escherichia coli 70S ribosome:: The mechanism of translocation [J].

Agrawal, RK ;

Penczek, P ;

Grassucci, RA ;

Frank, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6134-6138

[5] EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome [J].

Agrawal, RK ;

Heagle, AB ;

Penczek, P ;

Grassucci, RA ;

Frank, J .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (07) :643-647

[6] The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Moore, PB ;

Steitz, TA .

SCIENCE, 2000, 289 (5481) :905-920

[7] A 9Å resolution x-ray crystallographic map of the large ribosomal subunit [J].

Ban, N ;

Freeborn, B ;

Nissen, P ;

Penczek, P ;

Grassucci, RA ;

Sweet, R ;

Frank, J ;

Moore, PB ;

Steitz, TA .

CELL, 1998, 93 (07) :1105-1115

[8] Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit [J].

Ban, N ;

Nissen, P ;

Hansen, J ;

Capel, M ;

Moore, PB ;

Steitz, TA .

NATURE, 1999, 400 (6747) :841-847

[9]

Berg J M, 2001, Science, V291, P203

[10] A novel site of antibiotic action in the ribosome: Interaction of evernimicin with the large ribosomal subunit [J].

Belova, L ;

Tenson, T ;

Xiong, LQ ;

McNicholas, PM ;

Mankin, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (07) :3726-3731

← 1 2 3 4 5 6 7 →