Copper-free click-a promising tool for pre-targeted PET imaging

被引：35

作者：

Evans, Helen L. ^{[1
]}

Slade, Rozanna L. ^{[1
]}

Carroll, Laurence ^{[1
]}

Smith, Graham ^{[1
]}

Nguyen, Quang-De ^{[1
]}

Iddon, Lisa ^{[1
]}

Kamaly, Nazila ^{[1
]}

Stoeckmann, Henning ^{[2
]}

Leeper, Finian J. ^{[2
]}

Aboagye, Eric O. ^{[1
]}

Spivey, Alan C. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Comprehens Canc Imaging Ctr, Dept Surg & Canc, London SW7 2AZ, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 07期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CHEMISTRY;

D O I：

10.1039/c1cc16220a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [F-18]2-fluoroethylazide ([F-18]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

引用

收藏

页码：991 / 993

页数：3

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