Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process

被引：61

作者：

Bejot, Romain ^{[1
]}

Fowler, Thomas ^{[1
]}

Carroll, Laurence ^{[1
]}

Boldon, Sophie ^{[1
]}

Moore, Jane E. ^{[2
]}

Declerck, Jerome ^{[3
]}

Gouverneur, Veronique ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] AstraZeneca, Macclesfield SK10 4GT, Cheshire, England

[3] Siemens Mol Imaging, Oxford OX1 2EP, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 03期

关键词：

fluorine; positron emission tomography; radiopharmaceuticals; synthetic methods; PET; TC-99M; SCAVENGERS; COMPLEXES; CHEMISTRY; TRACER; CLICK;

D O I：

10.1002/anie.200803897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：586 / 589

页数：4

共 58 条

[1] Molecular imaging with PET [J].