Palladium-catalyzed carbene insertion and trapping with carbon nucleophiles

被引：94

作者：

Devine, Sean K. J. ^{[1
]}

Van Vranken, David L. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 10期

关键词：

D O I：

10.1021/ol800431w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium catalysts are shown to catalyze the three-component coupling of vinyl halides, trimethylsilyldiazomethane, and stabilized carbon nucleophiles. The reaction is believed to proceed through a palladium-carbene intermediate LX(R)Pd=CHSiMe3 that undergoes migration of the vinyl substituent to the electrophilic carbene center to generate an eta(3)-allylpalladium intermediate. The allylpalladium intermediate is attacked by the carbon nucleophile to generate a vinylsilane product.

引用

页码：1909 / 1911

页数：3

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