Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent

被引:59
作者
Cuesta, Marc [1 ]
Mendoza, Jorge [1 ]
Clesse, Daniel [1 ]
Pevet, Paul [1 ]
Challet, Etienne [1 ]
机构
[1] Univ Strasbourg, Dept Neurobiol Rythmes, Inst Neurosci Cellulaires & Integrat, CNRS,UMR 7168, F-67084 Strasbourg, France
关键词
circadian rhythm; suprachiasmatic; diurnal; photic; non-photic; Arvicanthis;
D O I
10.1016/j.expneurol.2007.11.026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The main circadian clock, localized in the suprachiasmatic nuclei (SCN) in mammals, can be synchronized by light and non-photic factors such as serotonergic cues. In nocturnal rodents, injections during the subjective day of the 5-HT1A/7 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or its positive enantiomer, induce behavioral phase-advances in correlation with decreased expression of two clock genes, Per1/2. In addition, 8-OH-DPAT and the selective serotonin reuptake inhibitor fluoxetine reduce light-induced phase-shifts during the subjective night. Beside the chronobiotic effects of serotonin, changes of serotonergic activity in humans have been involved in mood disorders, that are often associated with alterations in circadian rhythmicity. To get insights into the cireadian role of serotonin in diurnal species, we investigated its modulation of the SCN in Arvicanthis ansorgei housed in constant darkness. In striking contrast to nocturnal rodents, daily serotonin content in Arvicanthis SCN peaked during daytime while the sensitivity window of its SCN to (+)8-OH-DPAT occurred essentially during the subjective night. Moreover, fluoxetine produced behavioral phase-advances at circadian time (CT) 0 and CT 12. Expression of Per1/2, Rev-erb alpha/beta and Ror alpha/ 0 in the SCN was not modified after fluoxetine or (+)8-OH-DPAT injection. Furthermore, both treatments enhanced light-induced phase-advances and delays. Light responses of Per1 and Ror beta expression at CTO and those of Per2 and Rev-erb alpha at CT 12 were markedly altered by serotonergic activation. The present findings demonstrate that the serotonergic modulation of the SCN clock appears to differ between nocturnal species and the diurnal Arvicanthis. The potentiating effects of fluoxetine on light resetting in a diurnal rodent may be clinically relevant. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:501 / 513
页数:13
相关论文
共 74 条
[1]   Melatonin affects nuclear orphan receptors mRNA in the rat suprachiasmatic nuclei [J].
Agez, L. ;
Laurent, V. ;
Pevet, P. ;
Masson-Pevet, M. ;
Gauer, F. .
NEUROSCIENCE, 2007, 144 (02) :522-530
[2]   The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1 [J].
Akashi, M ;
Takumi, T .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (05) :441-448
[3]   A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light [J].
Albrecht, U ;
Sun, ZS ;
Eichele, G ;
Lee, CC .
CELL, 1997, 91 (07) :1055-1064
[4]   Response of the mouse circadian system to serotonin IA/2/7 agonists in vivo: Surprisingly little [J].
Antle, MC ;
Ogilvie, MD ;
Pickard, GE ;
Mistlberger, RE .
JOURNAL OF BIOLOGICAL RHYTHMS, 2003, 18 (02) :145-158
[5]   Circadian tryptophan hydroxylase levels and serotonin release in the suprachiasmatic nucleus of the rat [J].
Barassin, S ;
Raison, S ;
Saboureau, M ;
Bienvenu, C ;
Maître, M ;
Malan, A ;
Pévet, P .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (05) :833-840
[6]   Mice over-expressing the 5-HT1A receptor in cortex and dentate gyrus display exaggerated locornotor and hypothermic response to 8-OH-DPAT [J].
Bert, B ;
Fink, H ;
Hörtnagl, H ;
Veh, RW ;
Davies, B ;
Theuring, F ;
Kusserow, H .
BEHAVIOURAL BRAIN RESEARCH, 2006, 167 (02) :328-341
[7]   NEUROPEPTIDE-Y AND BEHAVIORALLY INDUCED PHASE-SHIFTS [J].
BIELLO, SM ;
JANIK, D ;
MROSOVSKY, N .
NEUROSCIENCE, 1994, 62 (01) :273-279
[8]   Reconsideration of 5-hydroxytryptamine (5-HT)7 receptor distribution using [3H]5-carboxamidotryptamine and [3H]8-hydroxy-2-(di-n-propylamino)tetraline:: Analysis in brain of 5-HT1A knockout and 5-HT1A/1B double-knockout mice [J].
Bonaventure, P ;
Nepomuceno, D ;
Kwok, A ;
Chai, WY ;
Langlois, X ;
Hen, R ;
Stark, K ;
Carruthers, N ;
Lovenberg, TW .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 302 (01) :240-248
[9]   Light and melatonin inhibit in vivo serotonergic phase advances without altering serotonergic-induced decrease of per expression in the hamster suprachiasmatic nucleus [J].
Caldelas, I ;
Challet, E ;
Saboureau, M ;
Pevet, P .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2005, 25 (01) :53-63
[10]   Circadian profile and photic regulation of clock genes in the suprachiasmatic nucleus of a diurnal mammal Arvicanthis ansorgei [J].
Caldelas, I ;
Poirel, VJ ;
Sicard, B ;
Pévet, P ;
Challet, E .
NEUROSCIENCE, 2003, 116 (02) :583-591