Weaving the Web of ER Tubules

被引:115
作者
Hu, Junjie [1 ,2 ]
Prinz, William A. [3 ]
Rapoport, Tom A. [4 ]
机构
[1] Nankai Univ, Dept Genet & Cell Biol, Coll Life Sci, Tianjin 300071, Peoples R China
[2] Nankai Univ, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China
[3] NIDDK, Lab Cell Biochem & Biol, NIH, Bethesda, MD 20892 USA
[4] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Cell Biol, Boston, MA 02115 USA
关键词
HEREDITARY SPASTIC PARAPLEGIA; ENDOPLASMIC-RETICULUM; MITOCHONDRIAL FUSION; MEMBRANE-PROTEINS; HOMOTYPIC FUSION; GOLGI-APPARATUS; ATLASTIN; MICROTUBULES; MECHANISMS; REVEALS;
D O I
10.1016/j.cell.2011.11.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that include the atlastins, Sey1p, and RHD3. © 2011 Elsevier Inc.
引用
收藏
页码:1226 / 1231
页数:6
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