Epicutaneous aeroallergen sensitization in atopic dermatitis infants -: determining the role of epidermal barrier impairment

被引:83
作者
Boralevi, F. [1 ]
Hubiche, T. [1 ]
Leaute-Labreze, C. [1 ]
Saubusse, E. [2 ]
Fayon, M. [3 ,4 ]
Roul, S. [1 ]
Maurice-Tison, S. [2 ]
Taieb, A. [1 ]
机构
[1] Bordeaux Childrens Hosp, Pediat Dermatol Unit, Bordeaux, France
[2] Univ Bordeaux 2, INSERM, U593, F-33076 Bordeaux, France
[3] CHU Bordeaux, Bordeaux Childrens Hosp, Pediat Pulmonol Unit, Bordeaux, France
[4] CHU Bordeaux, Bordeaux Childrens Hosp, CEDRE, Bordeaux, France
关键词
aeroallergen sensitization; allergens; atopic dermatitis; atopy; atopy patch test; skin prick test; transepidermal water loss;
D O I
10.1111/j.1398-9995.2007.01556.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. Objective: To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with AD. Methods: In this cross-sectional study we enrolled 59 AD children and 30 controls aged 3-12 months. Transepidermal water loss in uninvolved skin, specific immunoglobulin E, atopy patch test (APT) and skin prick tests were performed with respect to seven aeroallergens, i.e., Dermatophagoides pteronyssinus, D. farinae, cat, dog, birch pollen, ambrosia, and cockroach. Environmental conditions were assessed by a questionnaire, and the house dust mite (HDM) concentration was determined in dust samples. Results: Eighty-nine percent of AD infants had a positive APT vs one out of eleven controls. AD infants had a significantly higher mean TEWL than controls (27.4 vs 11.1 g/m(2)/h, P < 0001). Children with two or more positive APT had higher TEWL than the others (31.1 vs 19.0 g/m(2)/h, P < 0.025). No correlation was found between indoor APT results and exposure to HDM, cats, and dogs at home. Conclusions: This study confirms the high prevalence of delayed sensitization to indoor and outdoor aeroallergens in AD infants, and shows that the higher the TEWL, the higher the prevalence of sensitization to aeroallergens. These data are in favor of a major role of a constitutive epidermal barrier impairment in determining early atopen sensitization in infants with AD.
引用
收藏
页码:205 / 210
页数:6
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