Mechanisms of steroid-triggered programmed cell death in Drosophila

被引：154

作者：

Yin, VP ^{[1
]}

Thummel, CS ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Howard Hughes Med Inst, Dept Human Genet, Salt Lake City, UT 84112 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 02期

关键词：

ecdysone; autophagy; gene regulation; steroid hormones;

D O I：

10.1016/j.semcdb.2004.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies in Drosophila have provided a detailed understanding of how programmed cell death is regulated by steroid hormones during development. This work has defined a two-step hormone- triggered regulatory cascade that results, in the coordinate induction of central players in the death pathway, including the reaper and hid death activators, the Apaf-1 ortholog dark, and the dronc apical caspase gene. Recent transcriptional profiling studies have identified many new players in this pathway. In addition, genetic studies are providing new insights into the control of autophagic cell death and revealing how this response is related to, but distinct from, apoptosis. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：237 / 243

页数：7

共 46 条

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