Detection and clinical relevance of donor specific HLA antibodies: a matter of debate

被引：55

作者：

Roelen, Dave L. ^{[1
]}

Doxiadis, Ilias I. N. ^{[1
]}

Claas, Frans H. J. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

来源：

TRANSPLANT INTERNATIONAL | 2012年 / 25卷 / 06期

关键词：

histocompatibility and immunogenetics; presensitization; HIGHLY SENSITIZED PATIENTS; LEUKOCYTE ANTIGEN ANTIBODIES; SOLID-PHASE ASSAY; RENAL-TRANSPLANT PATIENTS; POSITIVE CROSS-MATCH; KIDNEY-TRANSPLANTATION; MEDIATED REJECTION; GRAFT FAILURE; COLLABORATIVE TRANSPLANT; ALLOGRAFT RECIPIENTS;

D O I：

10.1111/j.1432-2277.2012.01491.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The introduction of new sensitive assays for the detection of HLA antibodies on basis of their binding to isolated HLA molecules has got an enormous impact on the decision-making process with respect to donor selection for sensitized patients. In the past, when only complement-dependent cytotoxicity was used as a tool to define HLA alloantibodies, the presence of donor specific antibodies (DSA) before transplantation was considered a contraindication for renal transplantation with that donor. The interpretation of the current DSA results is far more difficult and leads to a lot of discussions and controversy. The problems associated with the use of solid phase assays for clinical decision making and possible solutions are discussed.

引用

页码：604 / 610

页数：7

共 57 条

[21] Toward performing transplantation in highly sensitized patients [J].

Fuggle, SV ;

Martin, S .

TRANSPLANTATION, 2004, 78 (02) :186-189

[22] Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification [J].

Gibney, Eric M. ;

Cagle, Linda R. ;

Freed, Brian ;

Warnell, Stephanie E. ;

Chan, Larry ;

Wiseman, Alexander C. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (09) :2625-2629

[23] Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: Are they relevant? [J].

Gupta, Arun ;

Iveson, Victoria ;

Varagunam, Mira ;

Bodger, Stephen ;

Sinnott, Paul ;

Thuraisingham, Raj C. .

TRANSPLANTATION, 2008, 85 (08) :1200-1204

[24]

Heinemann Falko M, 2006, Clin Transpl, P371

[25] Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation [J].

Ho, E. K. ;

Vasilescu, E. R. ;

Colovai, A. I. ;

Stokes, M. B. ;

Hallar, M. ;

Markowitz, G. S. ;

D'Agati, V. D. ;

Cohen, D. J. ;

Ratner, L. E. ;

Suciu-Foca, N. .

TRANSPLANT IMMUNOLOGY, 2008, 20 (1-2) :61-67

[26] Pretransplant IgG Subclasses of Donor-Specific Human Leukocyte Antigen Antibodies and Development of Antibody-Mediated Rejection [J].

Hoenger, Gideon ;

Hopfer, Helmut ;

Arnold, Marie-Luise ;

Spriewald, Bernd M. ;

Schaub, Stefan ;

Amico, Patrizia .

TRANSPLANTATION, 2011, 92 (01) :41-47

[27] C4d-Fixing Capability of Low-Level Donor-Specific HLA Antibodies Is Not Predictive for Early Antibody-Mediated Rejection [J].

Hoenger, Gideon ;

Wahrmann, Markus ;

Amico, Patrizia ;

Hopfer, Helmut ;

Boehmig, Georg A. ;

Schaub, Stefan .

TRANSPLANTATION, 2010, 89 (12) :1471-1475

[28] Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection [J].

Kimball, Pamela M. ;

Baker, Melissa A. ;

Wagner, Mary B. ;

King, Anne .

KIDNEY INTERNATIONAL, 2011, 79 (10) :1131-1137

[29] HYPERACUTE REJECTION OF KIDNEY ALLOGRAFTS ASSOCIATED WITH PRE-EXISTING HUMORAL ANTIBODIES AGAINST DONOR CELLS [J].

KISSMEYE, F ;

OLSEN, S ;

PETERSEN, VP ;

FJELDBORG, O .

LANCET, 1966, 2 (7465) :662-+

[30] Detection of Immunoglobulin G Human Leukocyte Antigen-Specific Alloantibodies in Renal Transplant Patients Using Single-Antigen-Beads is Compromised by the Presence of Immunoglobulin M Human Leukocyte Antigen-Specific Alloantibodies [J].

Kosmoliaptsis, Vasilis ;

Bradley, J. Andrew ;

Peacock, Sarah ;

Chaudhry, Afzal N. ;

Taylor, Craig J. .

TRANSPLANTATION, 2009, 87 (06) :813-820

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