How might cohesin hold sister chromatids together?

被引：74

作者：

Nasmyth, K ^{[1
]}

机构：

[1] IMP, Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2005年 / 360卷 / 1455期

关键词：

sister chromatid cohesion; cohesin; SMC and Kleisin proteins; chromosome segregation; mitosis; meiosis;

D O I：

10.1098/rstb.2004.1604

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.

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收藏

页码：483 / 496

页数：14

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