How might cohesin hold sister chromatids together?

被引:74
作者
Nasmyth, K [1 ]
机构
[1] IMP, Res Inst Mol Pathol, A-1030 Vienna, Austria
关键词
sister chromatid cohesion; cohesin; SMC and Kleisin proteins; chromosome segregation; mitosis; meiosis;
D O I
10.1098/rstb.2004.1604
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.
引用
收藏
页码:483 / 496
页数:14
相关论文
共 79 条
[1]   ATP hydrolysis is required for cohesin's association with chromosomes [J].
Arumugam, P ;
Gruber, S ;
Tanaka, K ;
Haering, CH ;
Mechtler, K ;
Nasmyth, K .
CURRENT BIOLOGY, 2003, 13 (22) :1941-1953
[2]   Positional cloning and characterization of mouse mei8, a disrupted allele of the meiotic cohesin Rec8 [J].
Bannister, LA ;
Reinholdt, LG ;
Munroe, RJ ;
Schimenti, JC .
GENESIS, 2004, 40 (03) :184-194
[3]   Requirement of heterochromatin for cohesion at centromeres [J].
Bernard, P ;
Maure, JF ;
Partridge, JF ;
Genier, S ;
Javerzat, JP ;
Allshire, RC .
SCIENCE, 2001, 294 (5551) :2539-2542
[4]   Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin [J].
Buonomo, SBC ;
Clyne, RK ;
Fuchs, J ;
Loidl, J ;
Uhlmann, F ;
Nasmyth, K .
CELL, 2000, 103 (03) :387-398
[5]   Chromosome cohesion: ring around the sisters? [J].
Campbell, JL ;
Cohen-Fix, O .
TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (10) :492-495
[6]   DNA interaction and dimerization of eukaryotic SMC hinge domains [J].
Chiu, A ;
Revenkova, E ;
Jessberger, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) :26233-26242
[7]   Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins [J].
Ciosk, R ;
Shirayama, M ;
Shevchenko, A ;
Tanaka, TU ;
Toth, A ;
Shevchenko, A ;
Nasmyth, K .
MOLECULAR CELL, 2000, 5 (02) :243-254
[8]   Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p [J].
CohenFix, O ;
Peters, JM ;
Kirschner, MW ;
Koshland, D .
GENES & DEVELOPMENT, 1996, 10 (24) :3081-3093
[9]   Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1β and SMC3 [J].
Eijpe, M ;
Offenberg, H ;
Jessberger, R ;
Revenkova, E ;
Heyting, C .
JOURNAL OF CELL BIOLOGY, 2003, 160 (05) :657-670
[10]   Structure, function and DNA composition of Saccharomyces cerevisiae chromatin loops [J].
Filipski, J ;
Mucha, M .
GENE, 2002, 300 (1-2) :63-68