Synthesis, characterisation, and biological studies of CdTe quantum dot-naproxen conjugates

被引:27
作者
Byrne, Stephen J.
le Bon, Bertrand
Corr, Serena A.
Stefanko, Maciej
O'Connor, Claire
Gun'ko, Yurii K.
Rakovich, Yury P.
Donegan, John F.
Williams, Yvonne
Volkov, Yuri
Evans, Paul
机构
[1] School of Chemistry, University of Dublin
[2] School of Physics, University of Dublin
[3] Department of Clinical Medicine, University of Dublin
[4] School of Chemistry and Chemical Biology, University College Dublin
关键词
CdTe; Enzymes; Live cells; Naproxen; Quantum dots;
D O I
10.1002/cmdc.200600232
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The first naproxen-QD conjugates have been synthesised and investigated. These conjugates demonstrated interesting photophysical properties, good stability in an aggressive enzymatic medium, and cellular localisation in macrophage (THP-1) cells. These nano-composites might have the potential to act as drug delivery and cellular imaging agents.
引用
收藏
页码:183 / +
页数:5
相关论文
共 30 条
[1]   Nanocrystal targeting in vivo [J].
Åkerman, ME ;
Chan, WCW ;
Laakkonen, P ;
Bhatia, SN ;
Ruoslahti, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621
[2]   LUMINESCENCE PROPERTIES OF CDSE QUANTUM CRYSTALLITES - RESONANCE BETWEEN INTERIOR AND SURFACE LOCALIZED STATES [J].
BAWENDI, MG ;
CARROLL, PJ ;
WILSON, WL ;
BRUS, LE .
JOURNAL OF CHEMICAL PHYSICS, 1992, 96 (02) :946-954
[3]   Surface modification to reduce nonspecific binding of quantum dots in live cell assays [J].
Bentzen, EL ;
Tomlinson, ID ;
Mason, J ;
Gresch, P ;
Warnement, MR ;
Wright, D ;
Sanders-Bush, E ;
Blakely, R ;
Rosenthal, SJ .
BIOCONJUGATE CHEMISTRY, 2005, 16 (06) :1488-1494
[4]   Optimisation of the synthesis and modification of CdTe quantum dots for enhanced live cell imaging [J].
Byrne, Stephen J. ;
Corr, Serena A. ;
Rakovich, Tatsiana Y. ;
Gun'ko, Yurii K. ;
Rakovich, Yury P. ;
Donegan, John F. ;
Mitchell, Siobhan ;
Volkov, Yuri .
JOURNAL OF MATERIALS CHEMISTRY, 2006, 16 (28) :2896-2902
[5]   Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].
Chan, WCW ;
Nie, SM .
SCIENCE, 1998, 281 (5385) :2016-2018
[6]   Protease-activated quantum dot probes [J].
Chang, E ;
Miller, JS ;
Sun, JT ;
Yu, WW ;
Colvin, VL ;
Drezek, R ;
West, JL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (04) :1317-1321
[7]   Cyclooxygenase in biology and disease [J].
Dubois, RN ;
Abramson, SB ;
Crofford, L ;
Gupta, RA ;
Simon, LS ;
Van De Putte, LBA ;
Lipsky, PE .
FASEB JOURNAL, 1998, 12 (12) :1063-1073
[8]   The electronic structure of semiconductor nanocrystals [J].
Efros, AL ;
Rosen, M .
ANNUAL REVIEW OF MATERIALS SCIENCE, 2000, 30 :475-521
[9]   Strongly photoluminescent CdTe nanocrystals by proper surface modification [J].
Gao, MY ;
Kirstein, S ;
Möhwald, H ;
Rogach, AL ;
Kornowski, A ;
Eychmüller, A ;
Weller, H .
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (43) :8360-8363
[10]   Thiol-capping of CdTe nanocrystals:: An alternative to organometallic synthetic routes [J].
Gaponik, N ;
Talapin, DV ;
Rogach, AL ;
Hoppe, K ;
Shevchenko, EV ;
Kornowski, A ;
Eychmüller, A ;
Weller, H .
JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (29) :7177-7185