ConsensusPathDB: toward a more complete picture of cell biology

被引：495

作者：

Kamburov, Atanas ^{[1
]}

Pentchev, Konstantin ^{[1
]}

Galicka, Hanna ^{[1
]}

Wierling, Christoph ^{[1
]}

Lehrach, Hans ^{[1
]}

Herwig, Ralf ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, Vertebrate Genom Dept, D-14195 Berlin, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

关键词：

EXPRESSION; NETWORKS; RESOURCE; DATABASE; PATHWAYS; PROTEINS; GENES;

D O I：

10.1093/nar/gkq1156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ConsensusPathDB is a meta-database that integrates different types of functional interactions from heterogeneous interaction data resources. Physical protein interactions, metabolic and signaling reactions and gene regulatory interactions are integrated in a seamless functional association network that simultaneously describes multiple functional aspects of genes, proteins, complexes, metabolites, etc. With 155 432 human, 194 480 yeast and 13 648 mouse complex functional interactions (originating from 18 databases on human and eight databases on yeast and mouse interactions each), ConsensusPathDB currently constitutes the most comprehensive publicly available interaction repository for these species. The Web interface at http://cpdb.molgen.mpg.de offers different ways of utilizing these integrated interaction data, in particular with tools for visualization, analysis and interpretation of high-throughput expression data in the light of functional interactions and biological pathways.

引用

页码：D712 / D717

页数：6

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