IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

被引:348
作者
Bailey, Charles C. [1 ]
Zhong, Guocai [1 ]
Huang, I-Chueh [2 ]
Farzan, Michael [1 ]
机构
[1] Scripps Res Inst, Dept Infect Dis, Jupiter, FL 33458 USA
[2] Univ Calif Riverside, Coll Nat & Agr Sci, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA
来源
ANNUAL REVIEW OF VIROLOGY, VOL 1 | 2014年 / 1卷
关键词
IFITM3; restriction factor; interferon; dengue virus; Ebola virus; flavivirus; influenza A virus; SARS coronavirus; viral entry; INDUCED TRANSMEMBRANE PROTEIN-3; VESICULAR STOMATITIS-VIRUS; IMPERFECTA TYPE-V; WEST NILE VIRUS; SARS CORONAVIRUS; S-PALMITOYLATION; INFLUENZA-VIRUS; B-LYMPHOCYTES; GENE-PRODUCTS; DENGUE VIRUS;
D O I
10.1146/annurev-virology-031413-085537
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Animal cells use a wide variety of mechanisms to slow or prevent replication of viruses. These mechanisms are usually mediated by antiviral proteins whose expression and activities can be constitutive but are frequently amplified by interferon induction. Among these interferon-stimulated proteins, members of the IFITM (interferon-induced transmembrane) family are unique because they prevent infection before a virus can traverse the lipid bilayer of the cell. At least three human IFITMproteins-IFITM1, IFITM2, and IFITM3-have antiviral activities. These activities limit infection in cultured cells by many viruses, including dengue virus, Ebola virus, influenza A virus, severe acute respiratory syndrome coronavirus, and West Nile virus. Murine Ifitm3 controls influenza A virus infection in vivo, and polymor-phisms in human IFITM3 correlate with the severity of both seasonal and highly pathogenic avian influenza virus. Here we review the discovery and characterization of the IFITM proteins, describe the spectrum of their antiviral activities, and discuss potential mechanisms underlying these effects.
引用
收藏
页码:261 / 283
页数:23
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