Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles

被引：329

作者：

Shen, QL ^{[1
]}

Shekhar, S ^{[1
]}

Stambuli, JP ^{[1
]}

Hartwig, JF ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 09期

关键词：

amination; heterocycles; homogenenous catalysis; P ligands; palladium;

D O I：

10.1002/anie.200462629

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long-lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1371 / 1375

页数：5

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