Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex

被引：12

作者：

Egami, Hiromichi ^{[1
,2
]}

Kamisuki, Shinji ^{[1
,2
]}

Dodo, Kosuke ^{[1
,2
]}

Asanuma, Miwako ^{[1
,2
]}

Hamashima, Yoshitaka ^{[2
]}

Sodeoka, Mikiko ^{[1
,2
]}

机构：

[1] Japan Sci & Technol, ERATO, Sodeoka Live Cell Chem Project, Wako, Saitama 3510198, Japan

[2] RIKEN, Adv Sci Inst, Wako, Saitama 3510198, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 22期

关键词：

NICHOLAS REACTION; CLEAVABLE LINKER; CHEMISTRY; NUCLEOTIDE; STRATEGIES; RESIN; PROBE;

D O I：

10.1039/c1ob06123b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt-phosphine complex supported on PS-PEG beads was found to react with a propargyl carbamate tag, and the tagged molecules immobilized on the beads could be released by acidic treatment through the Nicholas reaction pathway. These reactions work in aqueous media at 4 degrees C, so that this catch and release procedure is compatible with conditions generally used in biochemical experiments.

引用

页码：7667 / 7670

页数：4

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