Highly enantioselective Michael addition of malononitrile to α,β-unsaturated ketones

被引：82

作者：

Li, Xuefeng ^{[1
,2
,4
]}

Cun, Lingfeng ^{[1
,2
]}

Lian, Chunxia ^{[1
,2
]}

Zhong, Ling ^{[1
,2
]}

Chen, Yingchun ^{[3
]}

Liao, Jian ^{[1
,2
]}

Zhu, Jin ^{[1
,2
]}

Deng, Jingen ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmet Synth & Chirotechnol Sichuan Prov, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China

[3] Sichuan Univ, W China Sch Pharm, Chengdu 610041, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 02期

关键词：

D O I：

10.1039/b713129a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly enantioselective Michael addition of malononitrile to acyclic and cyclic alpha,beta-unsaturated ketones has been developed. The Michael reaction catalyzed by a primary amine derived from quinidine proceeded smoothly and provided the desired adducts with excellent enantioselectivities (83-97% ee).

引用

收藏

页码：349 / 353

页数：5

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