Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp.

被引：52

作者：

Volleková, A ^{[1
]}

Kostálová, D

Sochorová, R

机构：

[1] Slovak Postgrad Acad Med, Dept Dermatovenerol, Mycol Lab, Bratislava, Slovakia

[2] Comenius Univ, Fac Pharm, Dept Pharmacognosy & Bot, Bratislava, Slovakia

[3] Slovakofarma Co, Hlohovec, Slovakia

来源：

FOLIA MICROBIOLOGICA | 2001年 / 46卷 / 02期

关键词：

D O I：

10.1007/BF02873586

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range less than or equal to 50-greater than or equal to 1000 mg/L.

引用

页码：107 / 111

页数：5

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