Novel ceramide 1-sulfates, potent DNA topoisomerase I inhibitors isolated from the Bryozoa Watersipora cucullata

被引：29

作者：

Ojika, M

Yoshino, G

Sakagami, Y

机构：

[1] Grad. Sch. of Bioagricultural Sci., Nagoya University, Chikusa

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(97)00852-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two ceramide 1-sulfates 1 and 2 have been isolated from the Japanese Bryozoa Watersipora cucullata as new potent inhibitors of a human DNA topoisomerase I. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their absolute stereochemistry was elucidated by the optical data of degradation products. (C) 1997 Elsevier Science Ltd.

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页码：4235 / 4238

页数：4

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