Chronic infections and atherosclerosis

被引：35

作者：

Ayada, Kiyoshi ^{[1
]}

Yokata, Kenji ^{[1
]}

Kobayashi, Kazuko ^{[1
]}

Shoenfeld, Yehuda ^{[1
]}

Matsuura, Eiji ^{[1
]}

Oguma, Keiji ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Chem, Okayama 7008558, Japan

来源：

AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS | 2007年 / 1108卷

关键词：

anti-heat shock protein (HSP60); atherosclerosis; Helicobacter pylori (H. pylori); HEAT-SHOCK-PROTEIN; CHLAMYDIA-PNEUMONIAE INFECTION; HELICOBACTER-PYLORI INFECTION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; SERUM ANTIBODIES; HUMAN HEAT-SHOCK-PROTEIN-60; CAROTID ATHEROSCLEROSIS; IMMUNE-RESPONSES;

D O I：

10.1196/annals.1422.062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoinflammatory processes due to chronic infection are thought to be one of the definitive atherogenetic processes. Especially, anti-heat shock protein antibodies have been related to the prevalence of disease such as coronary artery disease or cerebral infarction, etc., resulted from atherosclerosis. Furthermore, the presence of HSP60specific T lymphocytes in circulation may increase the risk of atherosclerosis. We have recently demonstrated the evidences that Helicobacter pylori infection induced atherosclerosis in apoe(+/-)Idlr(+/-) mice and that Hp-anti-heat-shock protein specific Th1-dominant immune responses had a major involvement in the progression of atherosclerosis. These cellular immune responses caused autoimmunity against endogenous HSP60 (expressed on the stressed cells of vascular endothelium), due to the molecular mimicry. Therefore, an appropriate treatment with antibiotics or with anti-HSP60 antibodies, which regulates the Th1 induction, could sufficiently reduce the progression of atherosclerosis.

引用

页码：594 / 602

页数：9

共 55 条

[1]

Amberger A, 1997, CELL STRESS CHAPERON, V2, P94, DOI 10.1379/1466-1268(1997)002<0094:CEOIVE>2.3.CO

[2]

[3] Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques [J].

Benagiano, M ;

D'Elios, MM ;

Amedei, A ;

Azzurri, A ;

van der Zee, R ;

Ciervo, A ;

Rombolà, G ;

Romagnani, S ;

Cassone, A ;

Del Prete, G .

JOURNAL OF IMMUNOLOGY, 2005, 174 (10) :6509-6517

[4] T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions [J].

Benagiano, M ;

Azzurri, A ;

Ciervo, A ;

Amedei, A ;

Tamburini, C ;

Ferrari, M ;

Telford, JL ;

Baldari, CT ;

Romagnani, S ;

Cassone, A ;

D'Elios, MM ;

Del Prete, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) :6658-6663

[5] Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes [J].

Biasucci, LM ;

Liuzzo, G ;

Ciervo, A ;

Petrucca, A ;

Piro, M ;

Angiolillo, DJ ;

Crea, F ;

Cassone, A ;

Maseri, A .

CIRCULATION, 2003, 107 (24) :3015-3017

[6] Association between antibodies to heat shock protein 65 and coronary atherosclerosis - Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk [J].

Birnie, DH ;

Holme, ER ;

McKay, IC ;

Hood, S ;

McColl, KEL ;

Hillis, WS .

EUROPEAN HEART JOURNAL, 1998, 19 (03) :387-394

[7] Anti-cytomegalovirus (CMV) IgG antibody titer in patients with risk factors to atherosclerosis [J].

Blum, A ;

Peleg, A ;

Weinberg, M .

CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (03) :157-160

[8] T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses [J].

Buono, C ;

Binder, CJ ;

Stavrakis, G ;

Witztum, JL ;

Glimcher, LH ;

Lichtman, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (05) :1596-1601

[9]

Burian K, 2001, CIRCULATION, V103, P1503

[10] Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients [J].

Chung, SW ;

Kang, HS ;

Park, HR ;

Kim, SJ ;

Choi, JI .

JOURNAL OF PERIODONTAL RESEARCH, 2003, 38 (04) :388-393

← 1 2 3 4 5 6 →