Copper(I)-mediated oxidative cross-coupling between functionalized alkynyl lithium and aryl magnesium reagents

被引：71

作者：

Dubbaka, Srinivas Reddy ^{[1
]}

Kienle, Marcel ^{[1
]}

Mayr, Herbert ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 47期

关键词：

alkynes; cross-coupling; cuprates; nitrogen heterocycles;

D O I：

10.1002/anie.200703097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) All crossed: The reaction of unsaturated copper reagents with various alkynyl lithium compounds provides mixed lithium cuprates, which in the presence of chloranil undergo an oxidative coupling, thus leading to polyfunctional alkynes or enynes. Bromoenynes prepared by this method are readily converted into pyridine derivatives by a new ring closure that proceeds at low temperature (see scheme, tol = tolyl). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9093 / 9096

页数：4

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