The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

被引：2351

作者：

Mihaylova, Maria M. ^{[1
]}

Shaw, Reuben J. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Howard Hughes Med Inst, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 09期

关键词：

ACTIVATED PROTEIN-KINASE; ELEMENT-BINDING PROTEIN; GENE-EXPRESSION; DIRECT PHOSPHORYLATION; FATTY-ACID; HISTONE DEACETYLASES; TRANSCRIPTION FACTOR; HEPATIC STEATOSIS; UPSTREAM KINASE; SKELETAL-MUSCLE;

D O I：

10.1038/ncb2329

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.

引用

页码：1016 / 1023

页数：8

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