Rhodium(III)-Catalyzed Intermolecular Direct Amination of Aromatic C-H Bonds with N-Chloroamines

被引：200

作者：

Ka-Ho Ng

Zhou, Zhongyuan

Yu, Wing-Yiu ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

CATALYZED DIRECT AMINATION; CROSS-COUPLING REACTION; STEREOSELECTIVE-SYNTHESIS; ARYL; ACTIVATION; AMIDATION; RH; FUNCTIONALIZATION; ALDEHYDES; ALKYNES;

D O I：

10.1021/ol203046n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol Involving In situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

引用

页码：272 / 275

页数：4

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