cAMP/Ca2+ Response Element-Binding Protein Plays a Central Role in the Biogenesis of Respiratory Chain Proteins in Mammalian Cells

被引：40

作者：

De Rasmo, Domenico ^{[1
]}

Signorile, Anna ^{[1
]}

Papa, Francesco ^{[2
]}

Roca, Emilio ^{[1
]}

Papa, Sergio ^{[1
,3
]}

机构：

[1] Univ Bari, Dept Med Biochem Biol & Phys, I-70124 Bari, Italy

[2] Univ Bari, Dept Odontostomatol & Surg, I-70124 Bari, Italy

[3] CNR, Inst Biomembranes & Bioenerget, Bari, Italy

来源：

IUBMB LIFE | 2010年 / 62卷 / 06期

关键词：

CREB; mitochondrial biogenesis; mtDNA expression; HEART COMPLEX-I; CONTROLLING MITOCHONDRIAL BIOGENESIS; CYCLIC-AMP; GENE-EXPRESSION; TRANSCRIPTION FACTOR; SKELETAL-MUSCLE; COACTIVATOR PGC-1; ERR-ALPHA; REVERSIBLE PHOSPHORYLATION; OXIDATIVE-PHOSPHORYLATION;

D O I：

10.1002/iub.342

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, promotion of mitochondrial biogenesis by various agents involves cAMP and Ca2+-tmediated signal transduction pathways. Recruitment of these pathways results in phosphorylation by cAMP and Ca2+-dependent protein kinases of cAMP/Ca2+ response element-binding protein (CREB). Phosphorylation of CREB, bound to transcriptional complexes of target genes, activates a down-stream cascade of transcriptional complexes, which involve in sequence, the nuclear factors TORCs, PGC-1, NRF1 and NRF2, and the mitochondrial factor mitochondrial transcriptional factor A. CREB also binds directly to the D-loop of mitochondrial DNA and activates its expression. Activation of this network of transcriptional complexes results in concerted promotion of the expression of nuclear and mitochondrial genes encoding subunits of oxidative phosphorylation complexes. (C) 2010 IUBMB IUBMB Life, 62(6): 447-452, 2010

引用

页码：447 / 452

页数：6

共 72 条

[31] Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice [J].