Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori

被引：46

作者：

Gerrits, MM ^{[1
]}

Berning, M ^{[1
]}

Van Vliet, AHM ^{[1
]}

Kuipers, EJ ^{[1
]}

Kusters, JG ^{[1
]}

机构：

[1] Erasmus MC Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, NL-3015 GD Rotterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期

关键词：

D O I：

10.1128/AAC.47.9.2984-2986.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.

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页码：2984 / 2986

页数：3

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