Catalytic Batch and Continuous Flow Production of Highly Enantioenriched Cyclohexane Derivatives with Polymer-Supported Diarylprolinol Silyl Ethers

被引：72

作者：

Alza, Esther ^{[1
]}

Sayalero, Sonia ^{[1
]}

Cambeiro, Xacobe C. ^{[1
]}

Martin-Rapun, Rafael ^{[1
]}

Miranda, Pedro O. ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

SYNLETT | 2011年 / 04期

关键词：

asymmetric organocatalysis; domino process; Michael addition; Knoevenagel condensation; flow reactors; TRICYCLIC CARBON FRAMEWORKS; ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; 1,3-DIPOLAR CYCLOADDITIONS; ENANTIOSELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; MICHAEL ADDITION; DOMINO REACTIONS; CASCADE; IMMOBILIZATION;

D O I：

10.1055/s-0030-1259528

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diarylprolinol silyl ethers immobilized onto polystyrene have been employed as catalysts in the enantioselective domino Michael-Knoevenagel reaction of dimethyl 3-oxoglutarate and 3-substituted acrolein derivatives, including aliphatic ones. The best catalyst allows the preparation of highly functionalized cyclohexane derivatives in a straightforward and efficient manner, both under batch and continuous flow conditions.

引用

页码：464 / 468

页数：5

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