Surprising twists to exocyst function

被引：11

作者：

Clandinin, TR ^{[1
]}

机构：

[1] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA

来源：

NEURON | 2005年 / 46卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2005.04.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

What do neurons use the exocyst complex for? In this issue of Neuron, using mutations in one exocyst component, Mehta et al. reach the surprising conclusion that exocyst function is divisible: different components play distinct roles. These studies also suggest that the exocyst may regulate membrane insertion of cell adhesion molecules required for synaptic partner choice.

引用

页码：164 / 166

页数：3

共 15 条

[1]

BERONJA S, 2005, IN PRESS J CELL BIOL

[2] Making connections in the fly visual system [J].

Clandinin, TR ;

Zipursky, SL .

NEURON, 2002, 35 (05) :827-841

[3] Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells [J].

Grindstaff, KK ;

Yeaman, C ;

Anandasabapathy, N ;

Hsu, SC ;

Rodriguez-Boulan, E ;

Scheller, RH ;

Nelson, WJ .

CELL, 1998, 93 (05) :731-740

[4] Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex [J].

Hsu, SC ;

Hazuka, CD ;

Foletti, DL ;

Scheller, RH .

TRENDS IN CELL BIOLOGY, 1999, 9 (04) :150-153

[5] Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components [J].

Mehta, SQ ;

Hiesinger, PR ;

Beronja, S ;

Zhal, RG ;

Schulze, KL ;

Verstreken, P ;

Cao, Y ;

Zhou, Y ;

Tepass, U ;

Crair, MC ;

Bellen, HJ .

NEURON, 2005, 46 (02) :219-232

[6] The exocyst is a Ral effector complex [J].

Moskalenko, S ;

Henry, DO ;

Rosse, C ;

Mirey, G ;

Camonis, JH ;

White, MA .

NATURE CELL BIOLOGY, 2002, 4 (01) :66-72

[7] The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary [J].

Murthy, M ;

Schwarz, TL .

DEVELOPMENT, 2004, 131 (02) :377-388

[8] Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists [J].

Murthy, M ;

Garza, D ;

Scheller, RH ;

Schwarz, TL .

NEURON, 2003, 37 (03) :433-447

[9] Sec6 mutations and the Drosophila exocyst complex [J].

Murthy, M ;

Ranjan, R ;

Denef, N ;

Higashi, MEL ;

Schupbach, T ;

Schwarz, TL .

JOURNAL OF CELL SCIENCE, 2005, 118 (06) :1139-1150

[10] Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets [J].

Prakash, S ;

Caldwell, JC ;

Eberl, DF ;

Clandinin, TR .

NATURE NEUROSCIENCE, 2005, 8 (04) :443-450

← 1 2 →