The biology of Gram-positive sortase enzymes

被引：150

作者：

Paterson, GK ^{[1
]}

Mitchell, TJ ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 02期

关键词：

D O I：

10.1016/j.tim.2003.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Surface proteins of Gram-positive pathogens play various key roles in pathogenicity. Therefore, these proteins are of great interest in terms of understanding the infection process and have potential as targets for therapy. A major mechanism for the surface display of proteins by Gram-positive bacteria is sortase-mediated covalent attachment to the cell wall. The importance of sortase enzymes in the virulence of several pathogens is now becoming apparent, as are some of the more detailed workings of the enzyme and anchoring pathway. These recent advances are discussed.

引用

页码：89 / 95

页数：7

共 44 条

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