The biology of Gram-positive sortase enzymes

被引：150

作者：

Paterson, GK ^{[1
]}

Mitchell, TJ ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 02期

关键词：

D O I：

10.1016/j.tim.2003.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Surface proteins of Gram-positive pathogens play various key roles in pathogenicity. Therefore, these proteins are of great interest in terms of understanding the infection process and have potential as targets for therapy. A major mechanism for the surface display of proteins by Gram-positive bacteria is sortase-mediated covalent attachment to the cell wall. The importance of sortase enzymes in the virulence of several pathogens is now becoming apparent, as are some of the more detailed workings of the enzyme and anchoring pathway. These recent advances are discussed.

引用

页码：89 / 95

页数：7

共 44 条

[11] The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence
Garandeau, C
Réglier-Poupet, H
Dubail, L
Beretti, JL
Berche, P
Charbit, A
[J]. INFECTION AND IMMUNITY, 2002, 70 (03) : 1382 - 1390
[12] Hava D, 2002, MOL MICROBIOL, V45, P1389, DOI 10.1046/j.1365-2958.2002.03106.x
[13] Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA
Hava, DL
Hemsley, CJ
Camilli, A
[J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (02) : 413 - 421
[14] Genome of the bacterium Streptococcus pneumoniae strain R6
Hoskins, J
Alborn, WE
Arnold, J
Blaszczak, LC
Burgett, S
DeHoff, BS
Estrem, ST
Fritz, L
Fu, DJ
Fuller, W
Geringer, C
Gilmour, R
Glass, JS
Khoja, H
Kraft, AR
Lagace, RE
LeBlanc, DJ
Lee, LN
Lefkowitz, EJ
Lu, J
Matsushima, P
McAhren, SM
McHenney, M
McLeaster, K
Mundy, CW
Nicas, TI
Norris, FH
O'Gara, M
Peery, RB
Robertson, GT
Rockey, P
Sun, PM
Winkler, ME
Yang, Y
Young-Bellido, M
Zhao, GS
Zook, CA
Baltz, RH
Jaskunas, SR
Rosteck, PR
Skatrud, PL
Glass, JI
[J]. JOURNAL OF BACTERIOLOGY, 2001, 183 (19) : 5709 - 5717
[15] Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae
Iannelli, F
Oggioni, MR
Pozzi, G
[J]. GENE, 2002, 284 (1-2) : 63 - 71
[16] Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus
Ilangovan, U
Ton-That, H
Iwahara, J
Schneewind, O
Clubb, RT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) : 6056 - 6061
[17] On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis
Jonsson, IM
Mazmanian, SK
Schneewind, O
Verdrengh, M
Bremell, T
Tarkowski, A
[J]. JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (10) : 1417 - 1424
[18] The role of Staphylococcus aureus sortase A and sortase B in murine arthritis
Jonsson, IM
Mazmanian, SK
Schneewind, O
Bremell, T
Tarkowski, A
[J]. MICROBES AND INFECTION, 2003, 5 (09) : 775 - 780
[19] Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro
Kharat, AS
Tomasz, A
[J]. INFECTION AND IMMUNITY, 2003, 71 (05) : 2758 - 2765
[20] Inhibition of the bacterial surface protein anchoring transpeptidase sortase by medicinal plants
Kim, SW
Chang, IM
Oh, KB
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (12) : 2751 - 2754

← 1 2 3 4 5 →