The biology of Gram-positive sortase enzymes

被引：150

作者：

Paterson, GK ^{[1
]}

Mitchell, TJ ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 02期

关键词：

D O I：

10.1016/j.tim.2003.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Surface proteins of Gram-positive pathogens play various key roles in pathogenicity. Therefore, these proteins are of great interest in terms of understanding the infection process and have potential as targets for therapy. A major mechanism for the surface display of proteins by Gram-positive bacteria is sortase-mediated covalent attachment to the cell wall. The importance of sortase enzymes in the virulence of several pathogens is now becoming apparent, as are some of the more detailed workings of the enzyme and anchoring pathway. These recent advances are discussed.

引用

页码：89 / 95

页数：7

共 44 条

[31] Sortase: the surface protein anchoring transpeptidase and the LPXTG motif
Novick, RP
[J]. TRENDS IN MICROBIOLOGY, 2000, 8 (04) : 148 - 151
[32] Allelic variation in srtAs of Streptococcus suis strains
Osaki, M
Takamatsu, D
Shimoji, Y
Sekizaki, T
[J]. FEMS MICROBIOLOGY LETTERS, 2003, 219 (02) : 195 - 201
[33] Characterization of Streptococcus suis genes encoding proteins homologous to sortase of gram-positive bacteria
Osaki, M
Takamatsu, D
Shimoji, Y
Sekizaki, T
[J]. JOURNAL OF BACTERIOLOGY, 2002, 184 (04) : 971 - 982
[34] An embarrassment of sortases - a richness of substrates?
Pallen, MJ
Lam, AC
Antonio, M
Dunbar, K
[J]. TRENDS IN MICROBIOLOGY, 2001, 9 (03) : 97 - 101
[35] Anchoring of surface proteins to the cell wall of Staphylococcus aureus -: III.: Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring
Perry, AM
Ton-That, H
Mazmanian, SK
Schneewind, O
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (18) : 16241 - 16248
[36] Further evidence that a cell wall precursor [C55-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction
Ruzin, A
Severin, A
Ritacco, F
Tabei, K
Singh, G
Bradford, PA
Siegel, MM
Projan, SJ
Shlaes, DM
[J]. JOURNAL OF BACTERIOLOGY, 2002, 184 (08) : 2141 - 2147
[37] STRUCTURE OF THE CELL-WALL ANCHOR OF SURFACE-PROTEINS IN STAPHYLOCOCCUS-AUREUS
SCHNEEWIND, O
FOWLER, A
FAULL, KF
[J]. SCIENCE, 1995, 268 (5207) : 103 - 106
[38] SORTING OF PROTEIN-A TO THE STAPHYLOCOCCAL CELL-WALL
SCHNEEWIND, O
MODEL, P
FISCHETTI, VA
[J]. CELL, 1992, 70 (02) : 267 - 281
[39] Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
Tettelin, H
Nelson, KE
Paulsen, IT
Eisen, JA
Read, TD
Peterson, S
Heidelberg, J
DeBoy, RT
Haft, DH
Dodson, RJ
Durkin, AS
Gwinn, M
Kolonay, JF
Nelson, WC
Peterson, JD
Umayam, LA
White, O
Salzberg, SL
Lewis, MR
Radune, D
Holtzapple, E
Khouri, H
Wolf, AM
Utterback, TR
Hansen, CL
McDonald, LA
Feldblyum, TV
Angiuoli, S
Dickinson, T
Hickey, EK
Holt, IE
Loftus, BJ
Yang, F
Smith, HO
Venter, JC
Dougherty, BA
Morrison, DA
Hollingshead, SK
Fraser, CM
[J]. SCIENCE, 2001, 293 (5529) : 498 - 506
[40] Anchor structure of staphylococcal surface proteins IV. Inhibitors of the cell wall sorting reaction
Ton-That, H
Schneewind, O
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) : 24316 - 24320

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