Highly enantioselective Cu-catalyzed conjugate additions of dialkylzinc reagents to unsaturated furanones and pyranones: Preparation of air-stable and catalytically active Cu-peptide complexes

被引：126

作者：

Brown, MK ^{[1
]}

Degrado, SJ ^{[1
]}

Hoveyda, AH ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 33期

关键词：

asymmetric catalysis; conjugate addition; copper; enantioselectivity; zinc;

D O I：

10.1002/anie.200501251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The first generally effective method for catalytic asymmetric conjugate addition (ACA) of dialkylzinc reagents to unsaturated furanones and pyranones (see scheme) with different steric and electronic properties is reported. Synthesis, isolation, and characterization of catalytically active and air-stable chiral Cu-peptide complexes are also described. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5306 / 5310

页数：5

共 45 条

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