Themes and variations on ubiquitylation

被引：1216

作者：

Weissman, AM ^{[1
]}

机构：

[1] NCI, Canc Res Ctr, Lab Immune Cell Biol, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 03期

关键词：

D O I：

10.1038/35056563

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ubiquitylation - the conjugation of proteins with a small protein called ubiquitin - touches upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases that range from developmental abnormalities and autoimmunity to neurodegenerative diseases and cancer. A few years ago, we could only have dreamt of the complex arsenal of enzymes dedicated to ubiquitylation. Why has nature come up with so many ways of doing what seems to be such a simple job?.

引用

页码：169 / 178

页数：10

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